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It binds the oxygen until environmental conditions, such as heat or low pressure, allow it to release the oxygen again
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One way of combating drug resistance is to slow down the pace of evolution.
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Alteplase, reteplase, or tenecteplase with dosing as follows: Concurrent bolus of 60 units/kg (maximum: 4000 units), then 12 units/kg/hour (maximum: 1000 units/hour) as continuous infusion